Local application of Ketorolac decreased postoperative pain, shortened hospitalization periods, and reduced dependence on postoperative opioids in the context of musculoskeletal disorders, as deciphered from the findings of a systematic review. Researchers aimed to evaluate the effectiveness, safety characteristics, and postsurgical outcomes when utilizing locally administered Ketorolac injections for orthopedic conditions.

The assessment adhered to the guidelines set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Pertinent literature was explored by searching databases such as EMBASE and PubMed. The initial search yielded a total of 3,978 articles. Following a comprehensive evaluation, 21 complete-text documents were incorporated. In total, these 21 full-text manuscripts were examined, appraising a cohort of over 3,100 individuals who underwent a localized Toradol injection.

The reviewed studies consistently showcased a commendable safety profile for Ketorolac, whether administered systemically or through localized means. Clinical investigations illustrated that applying Ketorolac locally resulted in reduced postoperative pain, shortened hospitalization durations, and diminished postoperative reliance on opioids. Thus, local usage of Ketorolac offers a secure and efficient supplementary or alternative treatment for managing musculoskeletal ailments.