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Perioperative statin use in patients undergoing total knee arthroplasty is associated with reduced consumption of opioids.
Consumption of perioperative statin accompanies with enhanced postoperative opioid consumption following total knee arthroplasty executed under spinal anaesthesia, as evident from the findings of a recently published retrospective, observational study in the Journal of Regional Anesthesia & Pain Medicine.
Medical records of patients who underwent elective total knee arthroplasty under spinal anaesthesia were analyzed as inpatients in a tertiary hospital from January 2005 to October 2017. The postoperative day (POD) 3 of patients who took preoperative statins and of patients who did not receive preoperative statins were compared to assess the pain outcomes.
One thousand eighty-eight propensity-matched participants were selected for the final analysis. The patients who took statins showed a higher rate of total morphine equivalent consumption through POD 3 as compared to the non-statin group, but with comparable NRS pain scores. Although the rise in morphine consumption was minimal, therefore, its clinical significance remains debatable.
Regional Anesthesia & Pain Medicine
Association between perioperative statin use and postoperative pain after total knee arthroplasty.
Tak Kyu Oh et al.
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