The value of first desire to void and the frequency of nocturia following the treatment might become helpful indicators for the prognosis of IC/BPS.

In this study, thirty patients with IC/BPS experiencing 6-month intravesical hyaluronic acid were considered. The assessment before the treatment included a cystoscopy with hydrodistention of the bladder, urinalysis and urinary culture, a 3-day voiding diary and urinary cytology.

Urodynamic study was done before and after the treatment with hyaluronic acid. Symptomatic changes evaluated with the help of a visual analog scale, a questionnaire and the O'Leary-Sant symptom index and problem indexes (ICSI and ICPI).

Patient urgency scores, demographics, urodynamic results, urinary symptoms, ICSI/ICPI scores and pain score before and following the treatment of hyaluronic acid were compared.

ICSI/ICPI, urinary frequency, urgency, pelvic pain, bladder capacity and nocturia were considerably improved following the hyaluronic acid treatment.

Evaluating the urodynamic parameters, the volumes at first desire to void and maximum cystometric capacity were considerably enhanced following the hyaluronic acid treatment. 

Prior to hyaluronic acid treatment, a negative connection was present between the ICSI/ICPI and urodynamic parameters. However, no considerable associations were there following the treatment.

Before hyaluronic acid treatment, a negative connection was revealed between nocturia and first desire to void. However, after hyaluronic acid treatment, there was no considerable relationship between urodynamic parameters and urinary symptoms.

It was concluded that the urinary symptoms of IC/BPS improved following the treatment with hyaluronic acid as they are connected with maximum cystometric capacity and enhanced first desire to void.