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In women with thin endometrium, using platelet-rich plasma for intrauterine injections effectively improves endometrial lining thickness and reproductive outcomes.
Recent evidence issued in “BMC Pregnancy and Childbirth” highlighted the potential of platelet-rich plasma (PRP) for addressing thin endometrium, a frequent cause of infertility. The study sought to validate PRP as a promising therapeutic option for improving endometrial thickness and, consequently, boosting fertility outcomes.
A meta-analysis of randomized controlled trials (RCTs), examining the effects of PRP for thinning endometrium was conducted. Researchers searched databases like PubMed, Cochrane Library, and Embase. Data from selected RCTs were analyzed using fixed or random-effects models. Review Manager 5.4 software assessed bias risk and visualized results. Endometrial thickness was analyzed as a continuous variable with mean difference (MD) and 95% confidence interval as the effect size.
Other outcomes were binary variables, with relative risk (RR) used as the effect size. Eight RCTs with 678 patients were included. As found, PRP therapy dramatically improved endometrial thickness (MD: 1.23), clinical pregnancy rates (RR: 2.04), live birth rates (RR: 2.46), cycle cancellation rates (RR: 0.46), and embryo implantation rates (RR: 2.71) when compared to controls.
However, it did not show significant differences in spontaneous abortion rates (RR: 0.85), chemical pregnancy rates (RR: 1.84), and endometrial vascular improvement rates (RR: 1.10). No adverse events were noted. In conclusion, intrauterine autologous PRP infusion appeared to be an effective and safe option for treating thin endometrium. Additional robust large-scale studies are required to affirm these outcomes.
BMC Pregnancy and Childbirth
Efficacy of platelet-rich plasma in the treatment of thin endometrium: a meta-analysis of randomized controlled trials
Xinyuan Liu et. al.
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