A recent study showed that the use of Indomethacin suppositories can considerably lower the likelihood of elevated blood amylase levels and common bile duct calculi patient pancreatitis following choledocholithiasis endoscopic retrograde cholangiopancreatography (ERCP) in accordance with image denoising algorithm. Fusheng Gao et al. sought to investigate the value of magnetic resonance imaging (MRI) evaluation of Indomethacin to prevent hyperamylasemia and pancreatitis in common bile duct calculi patients.

In this retrospective study, 89 patient cases were divided into two groups, A and B, based on the various postoperative therapies. Group A was treated with a set of independent applications that suppresses pancreatic enzyme secretion following surgery, and group B was treated with the indole beauty Xinshuan treatment. The prevalence of postoperative hyperamylasemia and pancreatitis, and serum amylase levels in the study groups were evaluated. Both MRI with a denoising algorithm and conventional MRI were used to diagnose pancreatitis in patients in group B, and variations in the imaging properties and diagnostic rates of the two techniques were noted.

The diagnostic effectiveness was assessed using receiver operating characteristic (ROC) curves. In group B, postoperative pancreatitis and hyperamylasemia were far less common than in group A. In group B, there were 6 cases of postoperative pancreatitis, of which 2 (33.33%) were identified using conventional MRI and 5 (83.33%) through MRI using a denoising technique. The number of pancreatitis instances detected by MRI as per denoising algorithm was marginally greater in comparison with conventional MRI, despite the fact that there was no appreciable difference in diagnosis rates between the 2 techniques.

MRI images with a denoising method indicated that the number of instances of pancreatic edema, pancreatic duct/bile duct dilation, and abdominal effusion were all elevated as compared to conventional MRI images. According to ROC data, the area under the curve (AUC) for diagnosing postoperative pancreatitis using an MRI with a denoising algorithm was 0.855, while the sensitivity was 89.40%.

The sensitivity was 89.80%, the specificity was 83.20%, and the AUC of serum amylase for postoperative hyperamylasemia was 0.893, all of which had significant diagnostic efficacy. Thus, Indomethacin suppositories are clinically useful to reduce complications of postoperative hyperamylasemia and pancreatitis following ERCP.