After the two drug delivery systems under consideration, Ibuprofen-incorporated chitosan-based microspheres proved to have better analgesic and anti-inflammatory properties with considerable pain reduction, trismus, with reliable wound healing property than oral ibuprofen following mandibular third molar surgery.

Karthik KP and Balamurugan R examined the analgesic and anti-inflammatory properties of ibuprofen when directed via 2 drug delivery systems in 100 patients who needed surgery of obstructed mandibular third molars under local anaesthesia.

The study group had patients (50 patients) given ibuprofen-combined chitosan-based microspheres, which were packed into the third molar sockets following the surgery of impacted teeth. The control group had patients (50 patients) given ibuprofen oral 400 mg tablets following the surgery. On the 2^nd, 4^th and 7^th day of the surgery, patients were evaluated for pain, inflammation, and trismus.

The patients in the study group had greater pain relief and comparatively better mouth opening on the three evaluated days of the surgery. Meanwhile, the measurement of swelling did not display statistically significant results on any of these days. In the study group, 2 patients had wound gaping, and in the control group, 4 had wound gaping and 3 patients’ progressed dry socket.