In a randomized, double-blind clinical trial, Ibuprofen showed similar efficacy as Morphine and Paracetamol in pain relief and patient satisfaction in patients undergoing supratentorial brain surgery. Importantly, the use of Ibuprofen did not impact the blood clotting functions of the patients.

Researchers sought to compare intravenous infusion of Ibuprofen with Paracetamol-Morphine for brain surgery. An assessment of pain levels and satisfaction in people undergoing surgery for supratentorial brain neoplasms involved two groups, each comprising 50 volunteers (aged 18-65 years). In group I, a 400 mg intravenous infusion of Ibuprofen solution was given after the brain lesion removal, specifically at the initiation of dura closure, lasting for 30 minutes. In group II, an intravenous infusion of 0.07 mg/kg Morphine along with 1000 mg Paracetamol was given over 30 minutes.

Following the administration of Paracetamol-Morphine and Ibuprofen, the subject's satisfaction and pain level with the procedure were assessed. The satisfaction score of patients within the first 6 hours in the Ibuprofen group and the other group demonstrated a statistically significant variation, as depicted in Table 1:

However, the mean visual analog scale (VAS) values for the first, second, third, and fourth hours did not show a statistically significant difference, as shown in Table 2:

In the comparative analysis of laboratory indicators for platelet function between the two groups, none of the measured parameters exhibited a discernable difference during the three measurement periods. The use of Ibuprofen not only provided pain relief and patient satisfaction comparable to Morphine and Paracetamol but also exhibited a favorable outcome by not impacting the blood clotting functions of patients following surgery for supratentorial brain tumors.

Hence, it is recommended to utilize Ibuprofen for pain management after surgical procedures, aiming to mitigate the potential side effects associated with Morphine, such as sedation and respiratory depression. This approach is suggested without expressing concerns about platelet dysfunction or bleeding, particularly following brain surgery.