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Raised levels of uric acid during pregnancy significantly affect the likelihood of developing gestational diabetes mellitus.
According to a recent systematic review and meta-analysis performed by researchers, there is a noteworthy link between elevated uric acid levels during pregnancy and increased susceptibility to gestational diabetes mellitus (GDM). The study, which analyzed data from 23 relevant observational studies encompassing 105,380 participants, sheds light on the potential role of uric acid as a predictor of GDM.
Relevant observational studies were identified by conducting a search of Web of Science, Scopus, and PubMed/Medline databases until April 2022. For calculating pooled odds ratios (OR) and 95% confidence intervals (95% CI), a random effects model was employed. The study's authors also assessed the heterogeneity of the included studies using the I2 index. The findings, published in a reputable scientific journal, showed that elevated uric acid levels were strongly correlated with the risk of GDM.
The pooled analysis revealed a notable rise in GDM risk, with an odds ratio of 2.58 and a 95% confidence interval of 1.89-3.52. Further analysis conducted as part of the study indicated that estimating uric acid levels prior to the 20th week of gestation could be particularly valuable in predicting GDM, particularly in younger females. Subgroup analyses showed that higher uric acid levels prior to the 20th week of pregnancy were considerably linked with a raised risk of GDM, with an odds ratio of 3.26 and a 95% confidence interval of 2.26-4.71.
Moreover, the meta-regression analysis revealed a significant correlation between uric acid levels, the odds of developing GDM, and the participants' age. This correlation was found to be more pronounced in younger pregnant women. The implications of this study are substantial, as they highlight the importance of monitoring uric acid levels during pregnancy for early detection and potential intervention in cases of GDM.
Identifying at-risk individuals, especially younger women, may enable healthcare professionals to implement preventive measures and provide targeted care to minimize the risk and potential complications associated with GDM. It is crucial to note that further research and clinical validation are needed to establish the precise mechanisms behind the association between uric acid levels and GDM, as well as to explore potential interventions based on these findings. Nonetheless, this study represents a significant step forward in understanding the link between maternal uric acid levels and the risk of GDM.
Journal of Diabetes Investigation
Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose-response meta-analysis of cohort studies including 105,380 participants
Nikparast A et al.
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