Vitamin Cholecalciferol (D3) supplementation in high doses is effective for achieving adequate serum calcidiol (25OHD) levels in obese infertile males with low Vitamin D status, a study led by Rune Holt published in the “British Journal of Nutrition” illustrated. The study investigators explored the effect of Vitamin D3 supplements in high doses in achieving adequate levels of Vitamin D among infertile men with normal body mass versus overweight (obesity).

Spanning over 150 days, 307 infertile men were randomized to receive intervention therapy or placebo. The participants in the intervention group were firstly administered an oral dose of Vitamin D3 300,000 mg, followed by Vitamin D3 1400 mg supplementation every day and Calcium 500 mg. The baseline body mass index (BMI) was identified as a pre-defined subgroup.

The serum 25OHD was considerably greater in males with normal weight (BMI < 25 kg/m2) versus overweight men (BMI 25–30 kg/m2) and obese men (BMI > 30 kg/m2) (48 nmol/l versus 45 nmol/l and 39 nmol/l, respectively) at the baseline.

Following the intervention, males with normal weight, overweight and obese who received Vitamin D3 exhibited notably raised serum 25OHD levels than to their counterparts who were treated with a placebo (92 nmol/l versus 53 nmol/l; 92 nmol/l versus 53 nmol/l and 85 nmol/l versus 48 nmol/l, respectively). Hence, obese infertile men can achieve sufficient Vitamin D levels through high-dose Cholecalciferol supplementation.