An evidence-based clinical practice guideline issued in Dermatology provided valuable suggestions to prevent surgical site infection among adults following major extremity trauma. Investigators assessed the current best evidence linked with treatment for developing suggestions to prevent post-trauma surgical site infections. A total of 14 strong and moderate-strength recommendations were formed.

There should be early delivery of antibiotics to minimize deep infection risks in cases of open fracture in extremity trauma. For operative therapy of open fractures, the authors suggested preoperative antibiotics for the prevention of surgical site infections. People having open fractures must be conveyed to the operating room for debridement and irrigation as early as possible and preferably within twenty-four hours of injury.

For extremity trauma people undergoing surgical procedures, antibiotic prophylaxis using systemic clindamycin or cefazolin is suggested. However, preference is given to Gram-negative coverage for type III and possibly type II open fractures. For people with major extremity trauma undergoing surgery, the local antibiotic strategies might be advantageous.

For the initial management of open wounds, irrigation with saline solution (without additives) is advocated. The closure of an open wound is suggested whenever it is reasonable without any gross contamination. For improving outcomes or minimizing pin site infections, silver-coated dressings are not recommended.