According to a retrospective study, gastroparesis patients with comorbid generalized anxiety disorder (GAD) may be more susceptible to developing acute kidney injury (AKI). Such patients must be monitored for early signs of renal injury. Assessing the results of hospitalized gastroparesis people with and without GAD history was the goal of the study. Inpatient mortality, AKI, acute respiratory failure, sepsis, acute deep venous thrombosis, myocardial infarction, and intestinal blockage were among the outcomes that were examined in this trial.

Using multivariate logistic regression analysis, it was determined if GAD is an independent risk factor for the results. Overall, 22150 individuals with gastroparesis were evaluated, and 4,196 of them had GAD as a comorbid condition. There was a greater risk of AKI in the GAD group (adjusted odds ratio [aOR] 1.24). The aOR for inpatient mortality, myocardial infarction, sepsis, acute deep venous thrombosis, acute respiratory failure, and intestinal obstruction did not meet the level of statistical significance.

GAD is a risk factor for AKI in hospitalized people with gastroparesis. Due to the elevated risk of vomiting and nausea caused by GAD as well as the drugs used to manage it, such as Escitalopram and Duloxetine, this outcome may be ascribed to prerenal azotemia. AKI risk may also be influenced by the dual inflammatory conditions brought on by the co-existence of gastroparesis and GAD.