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Incorporating parental or TRIO MRI enhances diagnostic clarity for fetal brain anomalies, allowing physicians to provide accurate prognoses and enabling patients to make informed decisions during challenging times.
A new approach involving magnetic resonance imaging (MRI) of both parents and the fetus, known as DUO or TRIO MRI, could offer critical insights into prenatal diagnosis of fetal brain anomalies with uncertain outcomes. This family-based MRI strategy builds upon the success of Trio-exome sequencing, which has already improved diagnostic accuracy by 16% than single-exome methods.
In this single-centre retrospective case series, Carota Rodo et al. hypothesized that performing an MRI on one or both parents could be critical for fetal assessment and may contribute to a more accurate prognosis of the malformation. This study involved seven pregnant women with suspected fetal brain malformations. DUO or TRIO MRI significantly impacted prenatal guidance in five cases.
In three of those cases, a definitive diagnosis was achieved, highlighting conditions like periventricular nodular heterotopia (or subependymal grey matter heterotopia), mild tubulinopathy (cortical malformations), and dynein-associated neurodevelopmental disorder.
This method could be a game-changer in enhancing clarity for complex brain anomalies where traditional fetal assessments fall short. By incorporating parental MRIs, researchers suggest that this approach could refine prognosis in cases where fetal tests such as neurosonograms, fetal MRIs, and genetic screenings provide inconclusive results.
Prenatal Diagnosis
Parental or Trio Magnetic Resonance Imaging to Improve Prenatal Counseling in Brain Anomalies
Carota Rodo et al.
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