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For inducing remission in pediatric Crohn’s illness, partial enteral nutrition in combination with Crohn’s illness exclusion diet, adapted to align with the local culinary preferences, appears to be as efficacious as exclusive enteral nutrition.
In a pioneering study conducted at a leading tertiary center, researchers have found that Partial Enteral Nutrition (PEN) coupled with a modified Crohn's Disease Exclusion Diet (mCDED) holds promise for inducing endoscopic remission and mucosal healing in pediatric patients suffering from Crohn's disease (CD). This pilot prospective cohort trial focused on children with active CD and compared the efficacy of PEN + mCDED with Exclusive Enteral Nutrition (EEN).
Throughout the research period, 54 patients underwent screening, and 15 were excluded based on predetermined criteria, including six who were removed within the initial two days due to their inability to tolerate the enteral formula. The study comprised 14 volunteers in the PEN group and 19 in the EEN group. Evaluations were conducted at weeks 0, 1, 3, and 6, utilizing both clinical and lab parameters. Endoscopic examinations took place at both week 0 and week 6.
Key findings:
Hence, PEN + mCDED appears to be a viable alternative to induce endoscopic remission and mucosal healing in active CD-affected pediatrics. This real-world experience provides valuable insights into the potential benefits of this novel approach, opening novel avenues for the management of CD in the pediatric population.
Nutrients
Treatment of Active Crohn's Disease in Children Using Partial Enteral Nutrition Combined with a Modified Crohn's Disease Exclusion Diet: A Pilot Prospective Cohort Trial on Clinical and Endoscopic Outcomes
Darja Urlep et al.
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