Based on the latest review in ‘Spinal cord series and cases’; the case reports, case series and interviews suggested that usage of topical analgesics can be effectively used in the treatment of spinal cord injury (SCI)-associated neuropathic pain (NP).

T C Crul al. investigated the potential use of topical analgesics for NP due to SCI treatment. The studies on topical analgesics for SCI-related NP printed up to May 2019 were reviewed. Also, 8 people (aged 49-72 years) with SCI-related NP who treated with topical analgesics were interviewed regarding experience with topical analgesics.

Seven studies (5 case reports; 2 case series) were found that examined the use of topical analgesics for SCI-linked NP. Control treatment was not used in any study. Reduction in NP with time was described in all the studies. All but one of the interviewed people had an incomplete SCI. Topical agents comprising of baclofen, phenytoin, amitriptyline, ketamine or loperamide were used.

All disclosed pain relief of no less than 3 points on the 11-point numeric rating scale (NRS) during this treatment. The study authors added, ‘Future placebo-controlled studies are needed to explore the consequence of topical analgesics on SCI-linked NP.’