In comparison with late tracheostomy, early tracheostomy in ventilated SARS-CoV-2 people was linked with a shorter duration of invasive mechanical ventilation, ventilator-associated pneumonia, and intensive care unit (ICU) stay without altering the mortality rate, according to the findings of a meta-analysis. This study was carried out to assess the effect of early tracheostomy in comparison with late tracheostomy on outcomes of coronavirus-infected people.

Databases like Cochrane, Medline, Embase, Scopus database, medRxiv, bioRxiv, and Research Square were explored. In the study, early tracheostomy was characterized as a tracheostomy carried out fourteen days or less following commencement of ventilation while late tracheostomy was characterized as any time thereafter. The major endpoints ascertained were overall mortality, duration of invasive ventilation, and hospitalization duration. Utilizing a random-effects model, the mean differences (MD) or the pooled odds ratios (OR) with 95% confidence intervals were estimated.

A total of 14 studies and 2371 tracheostomized SARS-CoV-2 people were incorporated. Individuals who underwent early tracheostomy exhibited a considerable drop in hospitalization duration (1224 subjects; MD - 9.41 days) and duration of invasive mechanical ventilation (2098 subjects; MD - 9.08 days). Notably, mortality was stated for 2343 volunteers and was found to be similar between the groups (OR 1.09). Thus, early tracheostomy improves clinical outcomes in coronavirus-infected people.