According to a prospective, randomized, split-mouth, double-blind clinical trial, the use of platelet-rich fibrin (PRF) in alveolar filling after impacted third molars extraction significantly improves wound and bone healing, and also reduces postoperative pain and swelling. Investigators aimed to assess the postsurgical impact of PRF on bone and wound healing, periodontal complications, swelling, and pain following the extraction of impacted third molars.

In this study, after tooth removal, PRF was applied to the sockets before suturing the mucoperiosteal flap, while the control group's sockets received no treatment. The subjects were assessed for various variables, such as bone volume, trabecular thickness, trabecular distance, grey values, pain, swelling, and wound healing during the 90-day postoperative period. To analyze the data, the t-Student test and Wilcoxon test were employed at a significance level of 5%, and multiple comparisons were performed using the Friedman test.

The present study involved 44 surgeries with a mean patient age of 22.41 (± 2.75 years), and 72.73% of the participants were female. The application of PRF was linked with elevated means of trabecular thickness and bone volume.  In comparison to the control group, the experimental group exhibited significantly lower pain scores at 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, and 72 hours postoperatively.

Additionally, the experimental group showed lower mean swelling and significantly higher wound healing when compared to the control group.  Hence, alveolar filling using PRF leads to enhanced wound and bone healing, as well as a reduction in postsurgical pain and swelling. The study's results open up exciting possibilities for advancing dental treatment methodologies, ultimately benefiting patients and advancing the field of dentistry.