According to a double-blind randomized controlled trial, using a submucosal injection of Dexamethasone and Articaine solution following surgical extraction of molars is useful to minimize pain severity. Researchers sought to assess the advantages of submucosal injection of a Dexamethasone and Articaine combination on postsurgical pain following extraction of  mandibular third molar.

A total of 60 individuals who needed removal of mandibular third molars were incorporated. A submucosal injection was given by the surgeon right after the extraction.  Participants received an injection containing either Dexamethasone (10 mg) and Articaine (68 mg) (the "study group"), or the same amount of saline alone ("control group"). Seven days following the surgery, the degree of pain was rated with the aid of a questionnaire (Postoperative Symptom Severity [PoSSe] scale).

In comparison to those in the control group, patients in the study group had substantially reduced PoSSe pain intensity levels. In comparison with the control group, the study group exhibited considerably reduced cumulative postoperative PoSSe pain score. In terms of duration of pain, there was no discernible inter-group difference. Hence, following surgical removal of the mandibular third molars, submucosal injection of Dexamethasone/Articaine solution is beneficial in relieving pain.