As per the findings of a cross-sectional study, the presence of Helicobacter pylori (H. pylori) infection in blood appears to be connected with decayed teeth risk.  Furthermore, people with  a higher number of decayed teeth were highly likely to have systemic H. pylori infection. Komei Iwai et al. aimed to determine if H. pylori infection in blood was linked with dental caries in 752 Japanese adults.

Participants (239 females, 513 males, mean age 53.8 years) who underwent dental checkups and who tested positive for either H. pylori antibody test or the serum pepsinogen test as part of a human health examination were included. Notably, 83 patients (11%) had blood tests that revealed H. pylori infection. Individuals who had H. pylori infection in their blood exhibited a higher percentage of decaying teeth than individuals who were not H. pylori-infected.

Following adjustment for sex, age, gastric disease, regular dental checkups, dental caries, and history of antibiotic usage, the logistic assessment revealed that the presence of H. pylori in blood was positively related to those who had decayed teeth (odds ratio, 5.656). Moreover, the percentage of H. pylori infection in blood raised as per the number of decayed teeth. Hence, untreated dental caries may exert a significant impact on systemic H. pylori illness.