According to a case series, cryoneurolysis performed on alveolar nerves is a safe and user-friendly technique that enables long-lasting relief from neuropathic pain following dental surgery. Researchers aimed to investigate the impact of cryoneurolysis on alveolar nerves concerning chronic dental pain. After a positive diagnostic block on the relevant alveolar nerve, neuroablation was conducted utilizing a cryoprobe on 3 subjects who experienced ongoing pain following a dental extraction, and one patient following multiple tooth surgeries.

The impact of the intervention was evaluated with a pain numeric rating scale (NRS), as well as alterations in quality of life and medication dosage at day 7 and 3 months. At 3 months, 2 volunteers achieved over 50% pain relief, while two others experienced a 50% reduction (Figure 1):

As found, 1 subject successfully reduced their Pregabalin medication, another declined Amitriptyline usage by 50%, and one patient reduced the use of Tapentadol by 50%. There were no reports of direct complications. All patients experienced improvements in sleep and overall quality of life. The application of cryoneurolysis on alveolar nerves proves to be a favorable method that offers extended relief from neuropathic pain following dental surgery.