According to the findings of a four-year nationwide analysis published in "Inflammatory Bowel Diseases", Crohn’s disease (CD) did not significantly affect the outcomes of peptic ulcer disease (PUD) concerning acute PUD complications or mortality. Yassine Kilani et al. sought to look at the outcomes of PUD in CD patients.

Using information from the national inpatient sample database, this retrospective longitudinal trial examined individuals who were hospitalized with CD as their primary diagnosis. For assessing baseline traits of subjects having PUD primary diagnosis, with and without CD secondary diagnosis, a Chi-Square and T-Test were used.

The key endpoints of fatality, morbidity (inflammatory bowel disease [IBD] complications), total hospital charges (THC), and length of hospital stay (LOS), adjusted for patient and hospital factors were estimated using multivariate logistic regression assessment. Data analysis was performed utilizing STATA® Version 17.0 Software. The statistical significance threshold was set at p < 0.05.

Adult subjects (n = 582,710) with a primary diagnosis of PUD were recognized; 0.9% (n=3415) of these individuals also received a secondary diagnosis of CD. In comparison with individuals without CD, individuals with CD were younger (mean age: 61 years), had a higher percentage of females (54.5% vs 48.8%) and white patients (79% vs 70.9%), and had reduced rates of alcohol usage (4.9% vs 10.9%).

A clinically meaningful elevation in LOS by 1.33 days and THC by 19,273 US dollars was observed in CD sufferers. Having CD was not linked with any alteration in mortality (Odds ratio [OR] = 0.58) or PUD complications such as blood transfusions (OR = 0.92), septic shock (OR = 1.15), hypovolemic shock (OR = 1.00), perforation (OR = 1.76), peptic ulcer bleeding (OR = 1.15), and anemia (OR = 1.07) (Figure 1).

There were no cases of gastric cancer found in the participants. Regarding mortality and acute PUD complications, the incidence of CD does not significantly affect the outcomes of PUD. Nonetheless, hospitalization seems to be greater among CD patients. Longer-term robust trials would be needed to examine whether there is a connection between gastric cancer and CD.