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Pelvic floor rehabilitation plus intravaginal Diazepam may enhance patient outcomes in vulvodynia by notably improving hypertonicity and promoting treatment adherence.
Combining pelvic floor rehabilitation with vaginal Diazepam can alleviate pain and improve the quality of life of patients with vulvodynia, as per a pilot study published in the “Diseases” journal. Vulvodynia is a painful condition lasting at least three months, often linked to high-tone pelvic floor dysfunction. The research by Lucia Merlino et al. aimed to evaluate the effectiveness of 2 weekly sessions of pelvic floor rehabilitation (physical therapy) paired with a vaginal dose of Diazepam 5 mg given daily compared to rehabilitation alone.
In this single-centre, randomized study involving 20 participants (aged between 18 and 45 years) suffering from vulvar pain for at least three months, half received dual therapy while the other half underwent only pelvic floor rehabilitation. Comprehensive assessments, including pelvic floor ultrasounds and pain evaluations via the visual analog scale (VAS) and Marinoff Dyspareunia Scale, were conducted before treatment and at three- and six-months post-therapy.
As found, the angle of the elevator plate improved greatly, as did different ultrasound parameters linked with pelvic floor function. Specifically, the elevator plate angle increased from 8.2 to 9.55, levator symphysis distance ranged from 3.88 to 4.098, anorectal angle ranged from 121.9 to 125.49, Marinoff scale improved from 2.3 to 1.4, and the hiatal area diameter improved from 1.277 to 1.482. Notably, the VAS pain scores dropped from an average of 5.8 to 2.8 (p < 0.001), indicating a substantial reduction in pain levels.
Diseases
Evaluation of the Effectiveness of Combined Treatment with Intravaginal Diazepam and Pelvic Floor Rehabilitation in Patients with Vulvodynia by Ultrasound Monitoring of Biometric Parameters of Pelvic Muscles: A Pilot Study
Lucia Merlino et al.
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