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Coadministration
of propofol with esketamine minimizes EC50 of propofol during gastrointestinal
endoscopy.
In elderly people (aged 65-89 years) undergoing gastrointestinal (GI) endoscopy, the combination of propofol with esketamine minimized the propofol median effective concentration (EC50) during GI endoscopy versus administration of propofol without esketamine, according to a study published in The British Journal of Clinical Pharmacology. Researchers undertook a randomized controlled trial for determining the EC50 of propofol with varying doses of esketamine during GI endoscopy.
Overall,
90 participants were segregated into three arms: SK0 (control) arm (0 mg/kg
esketamine), SK0.25 arm (0.25 mg/kg esketamine), and SK0.5 arm (0.5 mg/kg
esketamine). Using plasma target-controlled infusion of propofol with varying
bolus doses of esketamine, anaesthesia was attained.
With the aid of the up-and-down method of Dixon, determination of EC50 of propofol for GI endoscopy was done. The adjacent concentration gradient was 0.5 μg/mL, while the initial plasma target concentration was 2.5 μg/mL. Estimation of cardiovascular variables was also done. Table 1 denotes propofol EC50 for GI endoscopy and the average percent alteration from baseline mean arterial pressure in the study groups.
Escalating
doses of esketamine with propofol are unlikely to elicit hypotension with a
shorter recovery time, concluded the study authors.
The British Journal of Clinical Pharmacology
The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: A randomized controlled trial
Hua Yang et al.
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