Combining Low Molecular Weight Heparin and Aspirin promotes successful and healthy pregnancy by enhancing the live birth rates in women with habitual spontaneous abortion.
Low Molecular Weight Heparin (LMWH)-Aspirin combination could be a key strategy for improving pregnancy outcomes while minimizing complications, as indicated by a recent comprehensive review and meta-analysis published in Medicine (Baltimore).
The incidence of recurrent or habitual spontaneous abortion is rising, affecting countless individuals worldwide who are struggling with repeated pregnancy losses. Often, such patients exhibit abnormal blood clotting. In clinical practice, LMWH and Aspirin are common therapeutic options, but their combination remains debated among healthcare providers. Fang Liu et al. reviewed data from 32 studies, involving 3,397 habitual spontaneous abortion patients, to assess both pregnancy success rates and potential adverse effects associated with the use of LMWH plus Aspirin.
As found, this combination therapy was associated with higher live birth rates and more full-term deliveries. It also appeared to drastically reduce the risk of miscarriage, preterm stillbirth, petechiae (blood spots), and thrombocytopenia (low platelet count), making it a safer option for many patients. The treatment was generally well-tolerated, with no significant increase in side effects such as gingival bleeding or gastrointestinal issues.
Medicine (Baltimore)
Clinical efficacy and adverse effects of LMWH combined with ASA in the treatment of RSA: A meta-analysis and systematic review
Fang Liu et al.
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