According to a single-blinded, randomized controlled trial, the administration of Bupivacaine via local injection resulted in reduced postoperative pain at the 4, 8, 12, and 24-hour intervals following the surgical removal of impacted mandibular third molars. The researchers aimed to assess the effectiveness of the local administration of Bupivacaine in alleviating pain after tooth extraction.

In total, 56 volunteers aged 18 to 30, with a mean age of 22.3±3.4 years, were randomly selected using Microsoft Office Excel spreadsheets. Subsequently, they were divided into two groups, with each group comprising 28 individuals, evenly split between females and males. Within the study group, 29 subjects were administered a 2 ml dose of 0.5% Bupivacaine via local infiltration near the extraction site, utilizing an insulin syringe to prevent any intraneural or intravenous infiltration.

The remaining 27 patients, constituting the control group, were given a 2 mL dose of normal saline utilizing the same administration method. All participants in both groups underwent a surgical procedure for the removal of their impacted mandibular third molars, conducted with the assistance of local anesthesia. At four specific time points: 4, 8, 12, and 24 hours after the operation, the assessment of pain levels was done utilizing a numeric rating scale (NRS).

A notable reduction in pain scores was observed in the study group compared to the control group throughout the postoperative period following the surgery. The administration of Bupivacaine via local injection did not result in any significant issues and effectively minimized postsurgical pain.