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Biologics and small molecules, like Janus kinase inhibitors, signal transducer and activator of transcription proteins inhibitors, anti-integrins, interleukin-12 and/or interleukin-23 inhibitors appear to be promising for IBD in pediatrics.
A recent study yielded a comprehensive summary of the novel pharmacological developments to tackle pediatric inflammatory bowel disease (IBD). The prevalence of pediatric IBD is on the rise worldwide, affecting both adults and children. Over 30% of patients are unresponsive to immune modulators and anti-tumor necrosis factor biologics. This narrative review offered insights into recent pharmacological advancements for managing pediatric IBD, encompassing innovative biological therapies.
Conducting an extensive PubMed Medline search, the study incorporated data from randomized controlled trials, suitable case reports, and retrospective and prospective observational studies. Additionally, guidelines and protocols from esteemed pediatric and adult gastroenterology societies, including the European Crohn's and Colitis Organization and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition were meticulously reviewed.
Preliminary real-world research indicated that cutting-edge biologics and small molecules, like signal transducer and activator of transcription proteins inhibitors, anti-integrins, interleukin-12 and/or interleukin-23 inhibitors, and Janus kinase inhibitors exhibit both safety and efficacy in combatting IBD among adults. Encouragingly, these findings also hint at promising outcomes for pediatric IBD. Despite significant strides in pharmacological treatments for IBD, ongoing research is imperative to solidify the usefulness of these interventions in the pediatric age group.
Extending the licensing of these novel treatments to children is deemed critical, given the mounting cases of non-responsiveness to conventional therapies. The study underscored the necessity for timely updates to international guidelines, ensuring the seamless incorporation of these innovative therapies into existing protocols.
Journal of Paediatrics and Child Health
Novel pharmacological developments in the management of paediatric inflammatory bowel disease: Time for guideline update - A narrative review
Rachel By Lee et al.
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