As per a study published in 'Experimental Gerontology', at least 2 monthly injection of intra-articular autologous platelet-rich plasma (IA aPRP) along with accurate injection of aPRP to the perimeniscal soft tissue structure, for example, the pes anserinus may be a feasible option in treating patients with moderate to severe knee osteoarthritis (OA).

In the geriatric patients, knee pain due to OA is frequently observed. The knee OA patients are generally complicated with soreness, joint pain, and weakness. A aPRP injection has been proved to be efficient for the treatment of mild knee OA. The effect of injecting aPRP in treating moderate to severe degrees of knee OA remains disputable.

Chen CPC et al. examined the effectiveness of aPRP in treating patients with at least grade 2 on the Kellgren and Lawrence system for the knee OA classification via a proteomic approach and a clinical evaluation tool of Lequesne index. The musculoskeletal ultrasound helped in the precise needle placement into the knee joint, and to the perimeniscal soft tissue for the injection of aPRP. Total of 3 monthly aPRP injections was implemented. In group 1, the patients received intra-articular (IA) injection only, whereas, in group 2, the patients received simultaneous IA plus the pes anserinus aPRP injections. There was a significant decline in the average SF total protein concentrations, and increases in the protein concentrations connected with chelation and anti-ageing (e.g./transthyretin, matrilin, and complement) after 2 monthly aPRP injections. Although, in group 2, a significant decrease in the protein concentrations associated with inflammation (e.g./immunoglobulin and apolipoprotein), and enhanced knee functional status was perceived. In group 2, SF becomes less susceptible to degeneration after aPRP injections.