A randomized controlled trial demonstrated that the healing time of peptic ulcer was shorter in the group treated with autologous platelet-rich plasma (aPRP) when compared to the control group. Ting Xu et al. sought to explore the effects of aPRP on healing of peptic ulcers, a multifactorial and complex disease.

In total, 27 peptic ulcer patients were randomized into two groups: (i) Control group (n=12): Treated with Rabeprazole, and (ii) PRP group (n=15): Treated with aPRP + Rabeprazole. Using ulcer size and symptom score, an assessment of therapeutic effect was done.

As found, all the candidates healed in 30 days. Regarding distinct independent variables, no profound inter-group difference was noted in the healing time. As per regression assessment, the healing time of peptic ulcer was 6.99 days shorter in PRP group versus control group. Candidates with higher symptom scores in the initial examination required more time to heal during therapy.

In comparison with the control group, the repaired ulcer in the PRP group was highly identical to the normal gastric mucosa tissue according to the endoscopic findings. aPRP therapy is beneficial to promote peptic ulcer healing. Even though additional follow-up trials are required to explore the duration of effectiveness of aPRP, the approach will be helpful to enhance clinical treatment of peptic ulcer, concluded the study authors.