A prospective monocentric study reported a significant connection between Helicobacter pylori (H. pylori) density and histopathological findings including intestinal atrophy and gastritis activity. The primary purpose of this research was to assess the relationship between colonization of H. pylori in the gastric mucosa and severity of histological markers of gastritis such as gastric atrophy, inflammatory activity, and intestinal metaplasia.

Patients naïve to any anti- H. pylori medication and with persistent H. pylori infection verified by histological investigation were included in the study. Data on epidemiology, endoscopy, and anathomopathology were obtained. There were 97 patients in all, with a mean age of 42.6 years [18-65 years] and a sex ratio of male/female=0.64.

Colonization of H. pylori was mild in 43.3 percent of patients, moderate in 47.4 percent, and severe in 9.3 percent of patients. Approximately, 10% of patients did not have gastritis, 33% had mild gastritis, 50.5% suffered from moderate gastritis, while severe gastritis was found in 6.2% of patients. Intestinal metaplasia and gastric atrophy were discovered in 10.3% and 44.3% of the population, respectively. Patients with mild rates of H. pylori colonization exhibited the highest degree of mild activity (59.5%).

A considerable link existed between gastritis activity and H. pylori severity. Colonization of H. pylori was found to be substantially related to gastric atrophy. No profound relationship was noted between colonization intensity and metaplasia. The study also found a statistically significant link between H. pylori density and histological findings such as gastritis activity and intestinal atrophy. Identification of the association between intensity of colonization and gastritis activity will aid physicians in more efficacious treatment and post-treatment follow-ups.