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Alternating day doses of Dutasteride 0.5 mg alleviate sexual dysfunction while maintaining prostate size reduction and voiding improvements, unlike daily dosing.
Posted in ‘Medicine, Baltimore’, a novel prospective study aimed to examine how variable doses of Dutasteride in combination affect patients with Benign Prostatic Enlargement (BPE).
BPE is a commonly observed disease in ageing men which affects about 90% of men in their 80's.
Included in this randomised study were 300 men who had moderate to severe urinary tract infections caused by BPE, and had a prostate volume of more than 40 cc. Three groups comprising 100 members each were administered the combination therapies under:
Patients were followed up every 3 months for a year to evaluate the efficacy and safety along with the medication’s effect on prostate size and erectile function.
After one year of treatment, each group experienced a notable improvement in their symptom scores. In terms of prostate size, Group I and II showed signs of prostate reduction but no changes were seen in Group III. After 12 months, Group I showed a substantial shift in sexual dysfunction.
Summing up, alternate-day Dutasteride is as effective as daily dosing for prostate size with better preserves sexual function.
Medicine, Baltimore
Effect of dose reduction of Dutasteride in combination with alpha-blockers in patients with lower urinary tract symptoms/benign prostatic enlargement
Abou-Farha, Mohamed et al.
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