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Fluticasone furoate nasal spray presents as a budget-friendly choice for patient care for allergic rhinitis with red, watery and itchy eyes.
Out of different corticosteroids available for treating the symptoms of allergic rhinitis (AR), Fluticasone furoate proved to be the most affordable option for relieving eye/ocular symptoms in patients with AR, a meta-analysis published in the Asian Pacific Journal of Allergy and Immunology culminated. Chadakan Yan et al. compared the cost-effectiveness of different intranasal corticosteroids - Budesonide, Mometasone furoate, Triamcinolone, and Fluticasone furoate for relieving itchy, watery and red eyes in AR patients in Thailand.
The total ocular symptoms score (TOSS) improvement effectiveness was assessed through a meta-analysis, comparing each corticosteroid to a placebo. A cost-effectiveness analysis, considered one-year costs and outcomes from a Thai societal viewpoint. The incremental cost-effectiveness ratio was equated. Probabilistic sensitivity analyses were also conducted to address parameter uncertainties. This analysis included a total of 3722 patients with seasonal AR out of 13 eligible randomized controlled trials. The percentages of efficacy of different therapies are mentioned in Table 1:
Compared to Budesonide, the incremental cost-effectiveness ratio of Fluticasone, Mometasone, and Triamcinolone was portrayed as THB-6,539.92, 4,593.83, and 1,401.24 respectively. The likelihood of using FFNS was deliberated cost-effective in 87.50% of patients from zero value followed by Mometasone (0.80%), Triamcinolone (5.40%), and Budesonide (6.30%) as per the outcomes of the cost-effectiveness acceptability curves. At a cost threshold beyond 20,000 Thai Baht, the use of FFNS was reflected as economically favorable or efficient for ocular manifestations in patients of AR.
Asian Pacific Journal of Allergy and Immunology
Meta-analysis and cost-effectiveness analysis of intranasal corticosteroid treatment in allergic rhinitis with ocular symptoms
Chadakan Yan et al.
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