The findings of a recent study indicated that the regimen including a mouthrinse containing cetylpyridinium chloride, zinc lactate, and fluoride presented higher antiplaque and antigingivitis effects in comparison with essential oils and control regimens. Gerson Pedro José Langa et al. carried out this assessment to explore the antiplaque and antigingivitis effects of three oral hygiene regimens.

The recruited participants were subjected to toothbrushing using standard fluoride toothpaste and manual toothbrush and either a mouthrinse containing essential oils in an alcohol-free base or a mouthrinse containing cetylpyridinium chloride, zinc lactate, and fluoride in an alcohol-free base. The control group was subjected to toothbrushing with the aid of a manual toothbrush and standard fluoride toothpaste and manual toothbrush only. In total, 120 individuals were randomized to study groups and continued the assigned regimens twice daily for six weeks.

Subjects were assessed for the Löe-Silness gingival index and Quigley-Hein plaque index at baseline, 4^th, and 6^th week. Utilizing analysis of variance and covariance, and paired t-test, the statistical assessment was carried out separately for plaque and gingival indexes. The cetylpyridinium chloride, zinc lactate, and fluoride group presented a further decline in dental plaque and Löe-Silness gingival index compared with essential oils and control groups after four and six weeks, as shown in the below table:

Thus, a mouthrinse containing cetylpyridinium chloride, zinc lactate, and fluoride is an effective protocol for controlling dental plaque and gingivitis.