For the patients with low back pain, the combination of Chlorzoxazone and Ibuprofen provides a significantly effective treatment as compared to the Ibuprofen monotherapy, as per a piece of information from a recently published open-label, prospective, multicenter study.

A total of 406 participants with acute low back pain were selected and obtained a single tablet of either combination of 500 mg Chlorzoxazone and 400 mg Ibuprofen or 400 mg Ibuprofen three times a day for up to 7 days. Pain improvement presented by Summed Pain Intensity Difference (SPID) and Visual Analogue Scale (VAS) at three and seven days postoperatively was considered as the primary outcomes.

C + I group exhibited a higher absolute mean change in VAS scores from baseline till day seven as compared to the I group. Further, reduced mean SPID was noticed for C + I group at days 3 and 7 as compared to the I group. No severe adverse effects or death were described. Common side effects were cold, fever, headache, stomach pain, and gastritis. 94.08% participants of C + I group and 77.33% participants of  I group presented an excellent to good response. Most of the patients of both groups exhibited good tolerability towards the medications. The C + I provide better effects as compared to the monotherapy.