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Physicians can recommend
14-Day Concomitant Therapy i.e. amoxicillin 1 g,
clarithromycin 500 mg and metronidazole 500 mg as well as omeprazole 20 mg, all
administered two times in a day for Helicobacter pylori treatment.
According an
observational multicenter study issued in ‘Journal of Clinical Medicine’, a 14-day concomitant therapy was found
to be very effective and well tolerated for the treatment of Helicobacter pylori (Hp) infection in primary care.
Hp infection causes numerous gastric disorders- dyspepsia
and peptic ulcer disease to fatal tumors such as gastric carcinoma, to name a
few!
The study researchers evaluated the efficacy of concomitant therapy for
14 days as a practical first-line treatment for Hp
infection in primary care. The pre and post treatment infection status was
assessed as per the local clinical practice procedure. The 14-day concomitant
comprised of: amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg
as well as omeprazole 20 mg, all administered two times in a day.
A total of 112 patients with a mean age of 46.7 ± 16.1 years were
registered. Uninvestigated dyspepsia (83%), functional dyspepsia (12.5%) and
peptic ulcer (3.5%) were the key indications for treatment. Hundred out of
112 patients achieved Hp eradication
rates: 89.3% by intention-to-treat (
Figure 1: Hp eradication rates by ITT and PP.
With no major side effects observed;
104 (92.8%) patients finished the therapy. Incidences of nausea and metallic
taste (mild side effects) were reported by 47 patients. Poor adherence to
treatment and notable adverse events were the variables linked with failure of
treatment.
Journal of Clinical Medicine
High Effectiveness of a 14-Day Concomitant Therapy for Helicobacter pylori Treatment in Primary Care. An Observational Multicenter Study
Llum Olmedo et al.
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