Nimesulide is a relatively COX-2 selective, Non-Steroidal Anti-Inflammatory Drug (NSAID) with analgesic and antipyretic properties.
Nimesulide is a relatively COX-2 selective, Non-Steroidal Anti-Inflammatory Drug (NSAID) with analgesic and antipyretic properties.
Nimesulide inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps to protect against the tissue damage that occurs during inflammation.
Tablet: 100 mg twice daily
Suspension: 50mg/5ml
Nimesulide is rapidly absorbed from the gastrointestinal tract. Plasma protein binding is 97.5% and peak plasma concentrations occurring at 1-3 hours. It is metabolized in liver and extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active) and also excreted in renal 50% and in fecal 29%. The elimination half life is approximately 2- 5 hours.
Use in the following conditions is contraindicated:
Common (affect between 1 in 10 and 1 to 100 people)
Uncommon (affect between 1 in 100 and 1 to 1000 people)
Very rare (affect less than 1 in 10,000 people)
Precaution should be taken in:
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