Categories
Change Password!
Reset Password!
Ketorolac is a nonsteroidal anti-inflammatory drug, with analgesic properties. It is also used to relieve pain caused by ankle sprain.
Ketorolac is a non-steroidal anti-inflammatory drug, with analgesic properties. It is also used to relieve pain caused by ankle sprain. Ketorolac is indicated for short term management (up to 10 days) of moderate to severe pain.
Ketorolac inhibits prostaglandin synthesis by competitive blocking cyclooxygenase (COX) enzyme. Ketorolac reduces the prostaglandins synthesis, chemicals that cells of the immune system make that cause the redness, fever, swelling and pain of inflammation and also effective to reduce non-inflammatory pain.
2% ketorolac gel should be used to reduce pain and swelling. Applied three or four times per day, however it may vary depending on the size of the affected area and response.
Ketorolac gel is rapidly absorbed. The skin permeation rate of ketorolac is 5.75±0.53. The plasma half-life of ketorolac is 6 hour. The protein binding of ketorolac is 99.2%. It can be used for short term pain management; an initial dose of ketorolac should be 30 or 60 mg. The terminal half life ranged from 6.6 to 9.7 hour. Topical route of administration may be a safe and effective alternative to the presently used oral routes.
Common (affecting between 1- 10 to 1 in 100)
Uncommon (affecting 1-100 to 1 in 1000)
Very rare (affecting less than 1 in 10,000)
Comments (0)