Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID), which is widely used in the treatment of patients with rheumatic diseases. It is known to reduce fever, inflammation or swelling and relieves pain.
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID), which is widely used in the treatment of patients with rheumatic diseases. It is known to reduce fever, inflammation or swelling and relieves pain. In case of arthritis, it is used to treat pain, swelling and associated stiffness. It inhibits cyclooxygenase actvity with reduction in production of prostaglandins such as PGE-2 and PGF-2a. It is also used to treat headaches, muscle aches and dental pain.
Pharmacological Class: NSAID
Ketoprofen is a non-steroidal anti-inflammatory of the propionics group, derivative of aryl-carboxylic acid. It shows anti-inflammatory effects by inhibition of cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen also have anti-bradykinin activity as well as lysosomal membrane-stabilizing action.
Adult dose for
Note: Not for use by children
Oral absorption of Ketoprofen has been found to be 94% ±4, volume of distribution as 0.11 l/kg and plasma protein binding as 95%. Presystemic metabolism is noted to be 45.5% ±4.5 and metabolism is reported to occur extensively by liver. Renal excretion accounts for 1% (unchanged) and its plasma half life is 1.5-4 hr.
In patients with established:
Common (affecting between 1 in 10 to 1 in 100)
Uncommon (affecting 1 in 100 to 1 in 1000)
Very rare (affecting less than 1 in 10,000)
Comments (0)