Rheumatoid arthritis (RA) is a constant requisite autoimmune inflammatory activity with a prevalence of ≥1% in western countries. Current treatment guidelines suggested methotrexate (MTX), a synthetic disease-modifying anti-rheumatic drug (sDMARD), also with glucocorticoids to be administered to most newly diagnosed RA patients. If MTX treatment fails to improve symptoms or fails to reach the therapy target, it is endorsed to switch to another sDMARD (e.g., sulfasalazine, leflunomide, hydroxychloroquine) or to add a biological DMARD (bDMARD) to MTX treatment.
Ankylosing Spondylitis (AS) is a class of arthritis that influences the spine. The symptoms involve pain and stiffness from the neck down to the lower back. AS influences both physical and emotional quality of life (QOL). The study aimed to assess the QOL of patients with AS, and recognise potentially modifiable factors associated with reporting poor QOL.
In general, two categories of pain perception have been described: a sharp first pain and a more delayed (and longer-lasting) sensation that is called other pain.
Many intercurrent factors may be included in the modulation of the pain message and its expression, such as the last experience of pain built along life.
A total knee replacement is a surgical manner whereby the diseased knee joint is displaced with artificial material. The knee is the hinge joint which gives motion at the point where the thigh meets the lower leg. Perioperative regional anaesthesia can protect from persistent postsurgical pain (PPSP) and improve outcome after total knee arthroplasty (TKA). Total knee replacement study was aimed to determine the impact of regional anaesthesia on PPSP and long-term functional outcome after TKA.
Acute pain is a common complication following cesarean section under general anesthesia. Post–cesarean section pain management is crucial for both the mother and the newborn. The present study published in the Journal of Pain Research compared the effects of patient-controlled intravenous analgesia (PCIA) using sufentanil or tramadol on postoperative pain control and initiation time of lactation in patients who underwent cesarean section under general anesthesia.