The effect of neuropathic pain symptoms on remission in patients with early rheumatoid arthritis

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The effect of neuropathic pain symptoms on remission in patients with early rheumatoid arthritis
Key Take-Away: 

Established rheumatoid arthritis (RA) pain, a severe arthritic condition is conventionally associated with peripheral inflammation of the joints. However, it is related to early RA as well? The answer to this question is explained in the following study.

Introduction
Neuropathic pain (NeP) shows significant association with established rheumatoid arthritis (RA) and affects the disease remission. However, during early RA stage, the effects of NeP was not investigated and therefore to evaluate the association between both, this study was conducted.

 

Method
The patients with slightly or highly active early RA with the >11score on the Simplified Disease Activity Index were selected. Patients were analysed for36-item Short Form Health Survey, EuroQoL-5 dimensions (EQ-5D) and painDETECT questionnaire (PDQ). Modified Rheumatic Disease Comorbidity Index (mRDCI) was used to assess the co-morbidity data associated with early RA stage. The presence NeP in every individual was noticed after the six months follow-up. Boolean remission criteria were also fulfilled.

 

Results
A total of 115 patients whose PDQ scores showed 13% NeP probability had completed the analysis. Twenty-five patients until the end of the follow-up met the Boolean remission criteria. The robust predictors govern not to being in Boolean remission were the baseline mRDCI and PDQ scores as per logistic regression. The ration of patients who achieved Boolean remission was only one in fifteen patients with concomitant NeP.

 

Conclusions
The remission of early RA can be affected by the presence of NeP. The perfect tool to measure central pain sensitisation among these patients was the PDQ.

Source:

Curr Rheumatol Rev

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/30081788

Original title of article:

The effect of neuropathic pain symptoms on remission in patients with early rheumatoid arthritis.

Authors:

Fausto Salaffi et al.

Exploratory, Rheumatoid Arthritis, Joints, EQ-5D, PDQ, mRDCT
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